Picoprazole吡考拉唑,78090-11-6

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Picoprazole

CAS No. : 78090-11-6

MCE 国际站：Picoprazole

产品活性：Picoprazole 是一种特异性的 H⁺/K⁺-ATPase 抑制剂，IC₅₀ 为 3.1±0.4 μM。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Proton Pump

In Vitro: Picoprazole inhibits the H⁺/K⁺-ATPase activity in a concentration-dependent manner. The IC₅₀ value is 3.1±0.4 μM. Picoprazole is a specific inhibitor of H⁺/K⁺-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl^- conductance by Cu²⁺-o-phenanthroline, indicating that the Cl^- conductance is part of the function of the H⁺/K⁺-ATPase. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated ¹⁴C-aminopyrine accumulation (H⁺ secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H⁺ secretion in a concentration dependent manner with IC₅₀ values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole.

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