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- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
YM 872
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
210245-80-0
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
| 规格： | 10 mg | 产品价格： | ￥8500.0 |
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Zonampanel
CAS No. : 210245-80-0
MCE 国际站：Zonampanel
产品活性：Zonampanel (YM 872) 是一种选择性的 AMPA 受体拮抗剂。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：iGluR
In Vitro: Zonampanel inhibits the human MRP4-mediated transport of [3H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [3H]oestradiol 17-D-glucuronide or [3H]methotrexate. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (Ki) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [14C]Zonampanel uptake is observed in these cells [Km values: 13.4 to 53.6 μM].
In Vivo: In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel.
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