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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
HM30181 mesylate; HM30181A mesylate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
849675-87-2
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥786.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥660.0 |
| 规格： | 10 mg | 产品价格： | ￥910.0 |
| 规格： | 25 mg | 产品价格： | ￥1740.0 |
| 规格： | 50 mg | 产品价格： | ￥2900.0 |
| 规格： | 100 mg | 产品价格： | ￥4400.0 |
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Encequidar mesylate
CAS No. : 849675-87-2
MCE 国际站：Encequidar mesylate
产品活性：Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) 是P-糖蛋白 (P-glycoprotein) 的有效竞争性抑制剂。
研究领域：Membrane Transporter/Ion Channel
作用靶点：P-glycoprotein
In Vitro: Treatment of 0.1 or 1 nM Encequidar (HM30181) lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively.
In Vivo: The plasma concentrations of Encequidar (HM30181) are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar (HM30181) in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction.
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