TDN345

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TDN345

CAS No. : 134069-68-4

MCE 国际站：TDN345

产品活性：TDN345 A 是一种 Ca²⁺ 拮抗剂，主要用于血管和老年痴呆疾病，例如阿尔茨海默症的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: TDN-345 (10 μM) significantly increases the intracellular NGF content in the time-course study. TDN-345 induces NGF synthesis/secretion at the concentrations of 0.1 μM; statistically significant at 1 μM. The ED₅₀ is 0.88 μM.

In Vivo: TDN-345 (0.1-1.0 mg/kg, p.o.) dose-dependently decreases the mortality and ischemic neurological deficit score when administered orally twice, 60 min before ischemia and 90 min after recirculation. Additionally, TDN-345 (0.2 or 1.0 mg/kg, p.o. once daily for 3 weeks after the onset of stroke) decreases the mortality and recurrence of stroke in SHRSP.

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