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- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
(-)-Cephaeline dihydrochloride; NSC 32944
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
5853-29-2
- 规格：
5 mg/10 mg/25 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
| 规格： | 50 mg | 产品价格： | ￥5800.0 |
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Cephaeline dihydrochloride
CAS No. : 5853-29-2
MCE 国际站：Cephaeline dihydrochloride
产品活性：Cephaeline dihydrochloride 是选择性的 CYP2D6 抑制剂，IC50 为 121 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC50s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (Ki) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield Kis of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.
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