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M1001
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/100 mg/1 mg/5 mg/10 mg/25 mg/50 mg
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 874590-32-6
MCE 国际站:M1001
产品活性:M1001 是一种较弱的低氧诱导因子-2α (HIF-2α) 激动剂。M1001 可以与 HIF-2α PAS-B 结构域结合,其 Kd 值为 667 nM。M1001 可用于慢性肾脏病的研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:HIF/HIF Prolyl-Hydroxylase
In Vitro: M1001 (10?μM) treatment shows increased expression of HIF-2 target genes in 786-O cells.?M1001 (10?μM) binds to HIF-2α and has the properties of a weak agonist.?M1001 (1-10?μM) reduces VHL binding to HIF-2α.
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