FT-1518,1313026-58-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

FT-1518

CAS No. : 1313026-58-2

MCE 国际站：FT-1518

产品活性：FT-1518 是一种选择性的，可口服的，有效的新一代 mTORC1 和 mTORC2 抑制剂，具有抗肿瘤的活性。

研究领域：PI3K/Akt/mTOR

作用靶点：mTOR

In Vitro: FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells.

In Vivo: FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  Rapamycin  |  Everolimus  |  MHY1485  |  Torin 1  |  AZD-8055  |  Sapanisertib  |  Dactolisib  |  Salidroside  |  Torin 2  |  Temsirolimus  |  L-Leucine  |  3BDO  |  JR-AB2-011  |  Omipalisib  |  PI-103  |  Torkinib  |  Camonsertib  |  Dihydromyricetin  |  NV-5138  |  RMC-5552  |  Vistusertib  |  D-α-Hydroxyglutaric acid disodium  |  Rheb inhibitor NR1  |  hSMG-1 inhibitor 11j  |  KU-0063794  |  PF-04691502  |  Aloe emodin  |  Polyphyllin I  |  Daphnetin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds