Serpin B5/Maspin 蛋白, Human (37

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Serpin B5/Maspin Protein, Human (375 a.a)

MCE 国际站：Serpin B5/Maspin Protein, Human (375 a.a)

Serpin B5/Maspin Protein, Human (375 a.a) 能抑制乳腺肿瘤的侵袭性和运动性。也是一种有效的血管生成抑制剂。

Synonyms: rHuMaspin; Serpin B5; PI-5

Species: Human

Source: E. coli

研究背景：Maspin is a unique member of the serpin family that shares extensive homology with monocyte-neutrophil elastase inhibitor, PAI-2 and other serpins. Maspin has been shown to inhibit invasion and motility of mammary tumors. Tumor transfectants expressing maspin exhibit decreased growth and metastasis in nude mice. Maspin gene expression is not detected in most breast tumors and loss of its expression is correlated with tumor invasiveness. Maspin is also found to be a potent angiogenesis inhibitor. In human breast tissue, maspin seems to be present more in luminal than myoepithelial cells, and it has been suggested that those maspin-expressing myoepithelial cells form a defensive barrier for the progression from ductal carcinoma in situ to more invasive carcinomas. A dispute exists regarding whether maspin acts as a protease inhibitor among biochemists.

蛋白编号：P36952-1 (M1-P375)

基因 ID：5268

产品分类：酶和调节子  |  蛋白酶抑制剂蛋白  |  丝氨酸蛋白酶抑制剂 Serpin  |  Serpin B5/Maspin

Categories：Enzymes & Regulators  |  Protease Inhibitors  |  Serpin (Protease Inhibitor)  |  Serpin B5/Maspin

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