IL-1 alpha 蛋白, Rat

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IL-1 alpha Protein, Rat

MCE 国际站：IL-1 alpha Protein, Rat

IL-1 alpha 是一种普遍存在的关键促炎细胞因子。IL-1 alpha 由单核细胞和巨噬细胞作为前蛋白产生，它经过蛋白水解加工并响应细胞损伤而释放，从而诱导细胞凋亡。IL-1 alpha 在炎症中发挥重要作用，并连接先天免疫和适应性免疫系统。IL-1 alpha 介导 NF-kappa-B 和三种 MAPK 途径 (p38、p42/p44、JNK) 的激活。IL-1 alpha protein, Rat 是重组蛋白, 由 156个 (S115-S270) 氨基酸组成，在大肠杆菌中表达。

Synonyms: Interleukin-1 alpha; IL-1 alpha; Il1a

Species: Rat

Source: E. coli

研究背景：IL-1 alpha (interleukin-1 alpha) is a major agonist of IL-1. IL-1α is present in all mesenchymal cells in particular, cells rich in IL-1α constitute tissues with a barrier function, such as keratinocytes in the skin, type 2 epithelial cells in the lung, the epithelium of the entire gastrointestinal tract, endothelial cells in blood vessels, and astrocytes in the brain.
The precursor of IL-1α (ProIL-1α) is processed by the Ca²⁺-dependent protease calpain (including caspase-1) into the mature 17 kDa form and the 16 kDa N-terminal cleavage product – the propiece of IL-1α, also termed IL-1α N-terminal peptide (IL-1NTP). The latent form of calpain is activated in cells under inflammatory conditions and especially upon loss of plasma membrane integrity, which occurs during necrosis. pro-IL-1α and mature IL-1α bind to IL-1R and induces the secretion of IL-6 and TNF.
IL-1α acts as an ‘alarmin’ and as a primum movens of tissue inflammation. IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation. IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation. IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes.

蛋白编号：P16598 (S115-S270)

基因 ID：24493

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-1  |  白细胞介素-1 alpha  |  细胞因子和生长因子  |  神经营养因子  |  白细胞介素-1  |  白细胞介素-1 alpha

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-1  |  IL-1 alpha  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  IL-1  |  IL-1 alpha

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