- ¥4896
- merck
- MABS25
- 进口
- 2025年12月09日
- WB
- M, H, R
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- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
多克隆
- 适应物种：
M, H, R
- 应用范围：
WB
- 抗体英文名：
Anti-VLDL-R Antibody, clone 6A6
- 抗体名：
极低密度脂蛋白受体VLDL-R抗体
- 规格：
500ul
Anti-VLDL-R Antibody, clone 6A6
重要规格表
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, H, R | WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MABS25 |
| Description | Anti-VLDL-R Antibody, clone 6A6 |
| Alternate Names |
|
| Background Information | Very low-density lipoprotein receptor (VLDL-R) belongs to the low density lipoprotein receptor family. VLDL-R binds particles containing apolipoprotein E (apoE) with high affinity. This includes VLDL, which after being bound by VLDL-R is then transported into the cell via endocytosis. It also binds to Reelin, stimulating Dab1 phosphorylation and the regulation of Tau phosphorylation. VLDL-R expression has been observed at high levels in adipose tissue, brain, heart, kidney, ovary, and skeletal muscle. It is not present in the liver. Defects involving deletion of the VLDL-R sequence are thought to be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH also known as DES), a cerebellar disorder characterized by delayed ambulation, moderate to severe mental retardation, primarily truncal ataxia. |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Applications | |
|---|---|
| Application | Anti-VLDL-R Antibody, clone 6A6 is an antibody against VLDL-R for use in WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the C-terminus of human VLDL-R. |
| Epitope | C-terminus |
| Clone | clone 6A6 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | This antibody recognizes VLDL-R at the C-terminus. |
| Isotype | IgG1λ |
| Species Reactivity |
|
| Species Reactivity Note | Demonstrated to react with mouse. Predicted to react with human and rat based on 100% sequence homology. |
| Antibody Type | Monoclonal Antibody |
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文献和实验组织利用。同时VLDL与HDL之间进行物质交换，一方面是将apoC和apoE等在两者之间转移，另一方面是在胆固醇酯转移蛋白(cholesteryl ester transfer protein)协助下，将VLDL的磷脂、胆固醇等转移至HDL，将HDL的胆固醇酯转至VLDL，这样VLDL转变为中间密度脂蛋白(IDL)。IDL有两条去路：一是可通过肝细胞膜上的apoE受体而被吞噬利用，另外还可进一步入被水解生成LDL(图5-5)。 图5-5 极低密度脂蛋白(VLDL)的代谢过程�
大鼠极低密度脂蛋白(VLDL) 酶联免疫分析（ ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定大鼠血清，血浆及相关液体样本中极低密度脂蛋白(VLDL) 含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中大鼠 极低密度脂蛋白(VLDL) 水平。用纯化的大鼠 极低密度脂蛋白(VLDL) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 极低密度脂蛋白
动脉内皮药等。 第一节 调血脂药 血脂以胆固醇酯（CE）和甘油三酯（TG）为核心，外包胆固醇（Ch）和磷脂（PL）构成球形颗粒。再与载脂蛋白（apo）相结合，形成脂蛋白溶于血浆进行转运与代谢。脂蛋白可分为乳糜微粒（CM）、极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）等。凡血浆中VLDL、IDL、LDL及apo B浓度高出正常为高脂蛋白血症，易致动脉粥样硬化。近年来证明HDL、apo A浓度低于正常，也为动脉粥样硬化危险
