- ¥780 - 2200
- LMAI Bio
- LM-4228R
- 进口/国产
- 2025年11月28日
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-4228R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
VLDL Receptor
- 抗体名：
极低密度脂蛋白受体抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human VLDL Receptor:551-650/873 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | VLDL Receptor |
| 中文名称 | 极低密度脂蛋白受体抗体 |
| 别 名 | Very low density lipoprotein receptor; VLDL R; VLDLR; VLDL-R; VLDLRCH. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 心血管 免疫学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VLDL Receptor:551-650/873 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: VLDL (very low density lipoprotein) cholesterol is one of the three major types of cholesterol found in blood. VLDL receptor plays an essential role in triglyceride metabolism. It binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). Subunit: Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17. Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Subcellular Location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Tissue Specificity: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver. Post-translational modifications: Ubiquitinated at Lys-839 by MYLIP leading to degradation. DISEASE: Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. Similarity: Contains 3 EGF-like domains. Contains 8 LDL-receptor class A domains. Contains 6 LDL-receptor class B repeats. SWISS: P98155 Gene ID: 7436 Database links: Entrez Gene: 7436 Human Entrez Gene: 22359 Mouse Entrez Gene: 25696 Rat Omim: 192977 Human SwissProt: P98155 Human SwissProt: P98156 Mouse SwissProt: P98166 Rat Unigene: 370422 Human Unigene: 4141 Mouse Unigene: 9975 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Heart (Mouse) Lysate at 40 ug Placenta (Mouse) Lysate at 40 ug Primary: Anti-VLDL Receptor (bs-4228R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution Predicted band size: 93kD Observed band size: 93kD  Blank control: 293T(blue). Primary Antibody:Rabbit Anti-VLDL Receptor antibody(bs-4228R), Dilution: 5μg in 100 1μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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文献和实验组织利用。同时VLDL与HDL之间进行物质交换，一方面是将apoC和apoE等在两者之间转移，另一方面是在胆固醇酯转移蛋白(cholesteryl ester transfer protein)协助下，将VLDL的磷脂、胆固醇等转移至HDL，将HDL的胆固醇酯转至VLDL，这样VLDL转变为中间密度脂蛋白(IDL)。IDL有两条去路：一是可通过肝细胞膜上的apoE受体而被吞噬利用，另外还可进一步入被水解生成LDL(图5-5)。 图5-5 极低密度脂蛋白(VLDL)的代谢过程�
VLDL大小为30-80nm，含有甘油三酯、胆固醇、胆固醇酯和磷脂，TG占50％左右，蛋白质部分为ApoAⅠ、AⅣ、B100 、C、E等。VLDL在肝脏合成，利用来自脂库的脂肪酸作为合成材料，其中胆固醇来自CM残粒及肝自身合成的部分。ApoB100 全部由肝合成，肝合成的VLDL分泌后经静脉进入血液，再由VLDL内ApoCⅡ激活LPL，并水解其内的TG。由HDL的LCAT作用生成的胆固醇酯经CETP转送给VLDL进行交换，而VLDL中余下的磷脂、ApoE、C转移给HDL
大鼠极低密度脂蛋白(VLDL) 酶联免疫分析（ ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定大鼠血清，血浆及相关液体样本中极低密度脂蛋白(VLDL) 含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中大鼠 极低密度脂蛋白(VLDL) 水平。用纯化的大鼠 极低密度脂蛋白(VLDL) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 极低密度脂蛋白
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