- ￥1350 - 3000
- Proteintech
- 66250-1-Ig
- 2025年10月13日
- WB, IHC, IF-P, ELISA
- Mouse
- human, mouse, rat, pig
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human CRP protein
- 亚型：
IgG2a
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat, pig
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF-P, ELISA
- 靶点：
C-Reactive Protein/CRP
- 抗体英文名：
C-Reactive Protein/CRP Monoclonal antibody
- 抗体名：
C-Reactive Protein/CRP Monoclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | serum from mouse injected with bacteria, pig liver tissue, rat liver tissue, serum from mouse injected with bacteria tissue |
| Positive IHC detected in | human liver tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human liver tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
66250-1-Ig targets C-Reactive Protein/CRP in WB, IHC, IF-P, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
| 经测试应用 | WB, IHC, IF-P, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat, pig |
| 文献引用反应性 | human, mouse, rat, monkey |
| 免疫原 |
CatNo: Ag9883 Product name: Recombinant human CRP protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-91 aa of BC020766 Sequence: MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGPNVLNWRALKYEVQGEVFTKPQLWP |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | C-reactive protein, pentraxin-related |
| 别名 | CRP, PTX1, C-reactive protein(1-205), C-Reactive Protein, C reactive protein |
| 计算分子量 | 224 aa, 25 kDa |
| 观测分子量 | 27 kDa |
| GenBank蛋白编号 | BC020766 |
| 基因名称 | CRP |
| Gene ID (NCBI) | 1401 |
| RRID | AB_2881638 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P02741 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
C-reactive protein (CRP) is an acute-phase serum protein synthesized by the liver in response to interleukin-6 (IL-6) during inflammation. The name of CRP derives from its ability to react with the C polysaccharide of Streptococcus pneumoniae. CRP is an annular, pentameric protein that belongs to the pentraxin family of proteins. CRP displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It is used mainly as a marker of inflammation.
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文献和实验| Species | Application | Title |
|---|---|---|
| rat | WB | Nat Commun Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse modelAuthors - Mengyan Hu |
| human | IF | Front Immunol Expression and clinical significance of interleukin-6 pathway in cholangiocarcinomaAuthors - Dongqing Gu |
| human | IHC | J Cell Mol Med Proteomic studies in VWA1-related neuromyopathy allowed new pathophysiological insights and the definition of blood biomarkersAuthors - Mohammed Athamneh |
| mouse | WB | Front Immunol Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.Authors - Anika Alberts |
Sci Rep A label-free fiber optic SPR biosensor for specific detection of C-reactive protein.Authors - Wenjia Wang | ||
| human | WB | Sci Rep C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.Authors - Anika Alberts |
免疫分子的命名根据不同的角度往往有不同的归类和命名，图3-3归纳了人白细胞分化抗原（CD）、粘附分子（AM）、免疫球蛋白超家族（IGSF）、细胞因子受体（CKR）、补体受体（CR）以及主要组织相容性复合体抗原（MHC）等免疫分子命名的相互关系。 （1）A表示CD命名范围中的粘附分子，如CD49a/CD29、CD49b/CD29、CD49c/CD29、CD49d/CD29、CD
稳定区或恒定区（constantregion，C区）。 V区位于N端，H链和L链各有3个高变区（hypervariableregion），其中的氨基酸残基种类和顺序特别多变。这此都与识别抗原直接有关，为Ig分子的抗原结合部位，故亦称为互补决定区（complementaritydeterminingregion，CDR）。 可变区中的其他氨基酸残基称为构架区（frameworkregion，FR），大约占整个V区近75%，其顺序很少变化（约5%）。FR的功能为支持CDR，并维持V区
的细胞群所产生的，所以它的免疫球蛋白属同一类型，质地纯一，而且它是针对某一抗原决定簇的，因此特异性强，亲合性也一致。单克隆抗体（McAb）的特性和常规血清抗体的特性比较见2-3。 表2-3 单克隆抗体（McAb）和常规免疫血清抗体的特性比较 单克隆抗体的制备方法如下。 （一）动物的选择与免疫 1．动物的选择 纯种BALB/C小鼠，较温顺，离窝的活动范围小，体弱，食量及排污较小，一般环境洁净的实验室均能饲养成活。目前开展杂交瘤技术的实验室多选用纯种BALA
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