- ￥1350 - 3000
- Proteintech
- 10842-1-AP
- 2025年10月13日
- WB, IHC, IF/ICC, IF-Fro, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human a-Synuclein protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IF/ICC, IF-Fro, ELISA
- 靶点：
Alpha Synuclein
- 抗体英文名：
Alpha Synuclein Polyclonal antibody
- 抗体名：
Alpha Synuclein Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | mouse brain tissue, human brain tissue, rat brain tissue |
| Positive IHC detected in | mouse brain tissue, human kidney tissue, human placenta tissue, human testis tissue, human skin tissue, human lung tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-Fro detected in | rat brain tissue |
| Positive IF/ICC detected in | SH-SY5Y cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)-FRO | IF-FRO : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
10842-1-AP targets Alpha Synuclein in WB, IHC, IF/ICC, IF-Fro, IP, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IF/ICC, IF-Fro, ELISA |
| 文献引用应用 | WB, IHC, IF, IP, CoIP, ELISA |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat, yeast, zebra finch |
| 免疫原 |
CatNo: Ag1285 Product name: Source: e coli.-derived, PKG Tag: GST Domain: of Sequence: |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | synuclein, alpha (non A4 component of amyloid precursor) |
| 别名 | 1, a-synuclein, SNCA, Alpha-synuclein, NACP |
| 计算分子量 | 14 kDa |
| 观测分子量 | 15-19 kDa |
| GenBank蛋白编号 | BC013293 |
| 基因名称 | Alpha Synuclein |
| Gene ID (NCBI) | 6622 |
| RRID | AB_2192672 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P37840 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Alpha Synuclein (α-syn) is a 14-19 kDa phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation was identified as a cause of familial Parkinson's disease (PD). Aggregated and hyper-phosphorylated forms of α-syn protein are the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV). This antibody can recognize all the isoforms of α-syn.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Transl Neurodegener Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy modelsAuthors - Alice Drobny |
| mouse | IF | Aging Dis MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.Authors - Chunling Xue |
| human | IHC | Acta Neuropathol Commun Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.Authors - Ivan Martinez-Valbuena |
| mouse | WB,IHC | Aging Cell Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.Authors - Kanmin Mao |
| human | WB | Acta Pharmacol Sin Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.Authors - Wen-Li Dong |
| mouse | WB,IHC,IF | J Neurosci Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.Authors - Weili Yang |
【求助】请问alpha-synuclein的等电点是多少呢？
pophjp 请问alpha-synuclein的等电点是多少呢？不胜感激~-~ Fasta921 pophjp wrote: 请问alpha-synuclein的等电点是多少呢？不胜感激~-~ http://expasy.org/tools/pi_tool.html 输入你蛋白的氨基酸序列就知道PI pophjp
Adult transgenic fruit flies (Drosophila melanogaster ) carrying the human gene coding for the protein α-synuclein were tested for geotactic, locomotor, and phototactic behaviors as well as α-synuclein expression. Specific assays in adult
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