- ￥1350 - 3000
- Proteintech
- 10445-1-AP
- 2025年10月13日
- WB, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human HIST3H2A protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
Histone H2A type 3
- 抗体英文名：
Histone H2A type 3 Polyclonal antibody
- 抗体名：
Histone H2A type 3 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | human brain tissue, fetal human brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
10445-1-AP targets Histone H2A type 3 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA |
| 文献引用应用 | WB, IP, IF, IHC |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag0374 Product name: Recombinant human HIST3H2A protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-130 aa of BC001193 Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | histone cluster 3, H2a |
| 别名 | HIST3H2A, histone, histone cluster 3, H2a, Histone H2A, Histone H2A type 3 |
| 计算分子量 | 14 kDa |
| 观测分子量 | 14-18 kDa |
| GenBank蛋白编号 | BC001193 |
| 基因名称 | Histone H2A type 3 |
| Gene ID (NCBI) | 92815 |
| RRID | AB_2116701 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q7L7L0 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Histone H2A type 3, it is expected to be located in the nucleus, and the protein is enriched in the brain tissue. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. The molecular weight of Histone H2A type 3 is 14 kDa.
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文献和实验| Species | Application | Title |
|---|---|---|
| human,mouse | WB,IP,IF | Nucleic Acids Res H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor.Authors - Libo Su
|
| mouse | WB | Nucleic Acids Res Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.Authors - Tianjin Shen |
| mouse | IHC | EMBO Rep MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors.Authors - Hongyan Ma |
| human | WB | BMC Cancer HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosisAuthors - Lihong Yang |
Site-directed hydroxy radical mapping of nucleosome positions in vitro
and Davey, 2003). Procedure Preparation of Derivatised Octamer Refold and purify histone octamer containing histones H2A wild type, H2B wild type, H3 Cys110Ala and H4 Ser47Cys following standard methods (Dyer et al., 2004) (see note 1);
Isolation of Histones and Nucleosome Cores from Mammalian Cells
is often important for understanding mechanisms of regulation of transcription and other processes that occur on DNA. The basic unit of chromatin is the nucleosome core, containing two copies each of the core histones H2A, H2B, H3, and H4 to form a histone octamer
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
1, mRNA 8138 NM_004689 Homo sapiens metastasis associated 1 (MTA1), mRNA 506 NM_001848 Homo sapiens collagen, type VI, alpha 1 (COL6A1), mRNA 757 NM_004068 Homo sapiens adaptor-related protein complex 2, mu 1 subunit (AP2M1), mRNA 2188 NM
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