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- 文献和实验
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- 英文名：
Shanghai Model Organisms Center, Inc.
- 库存：
1
- 供应商：
上海南方模式生物科技股份有限公司
- 规格：
品系
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文献和实验Genetic Models of Parkinsons Disease
patients. The latest mouse genetic technology may offer, at least in part, a relief for these challenges through the timed control of protein expression or gene knockout. Both can be achieved by the use of the Tamoxifen inducible CreERT2 gene switch
by administration of tamoxifen to the animal. Here we describe how tamoxifen-dependent Cre recombinases, so-called CreER recombinases, work and how they can be used to generate time- and tissue-specific mouse mutants. The focus will be on the CreERT2 recombinase
Generating Conditional Knockout Mice
in many different cell types. A growing number of CreERT2 transgenic mice further allows for inducible inactivation of floxed alleles in adult mice upon administration of tamoxifen. This chapter covers the design and construction of loxP flanked alleles and refers
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