重组人IL-33 蛋白

Interleukin-33, also known as IL33, C9orf26, IL1F11 and NFHEV, belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes.,but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-魏B and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells.

·Description
Novoprotein Recombinant Human IL-33/HIS tag produced by e.coli expression system.Target protein is expressed with sequence (Ser112-Thr270) of Human (Uniprot #O95760) fused with a His tag at the C-terminus.

·Quality Control

Purity: Greater than 90.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.

Endotoxin:Less than 0.1ng/μg (1EU/μg) of IL-33/HIS tag (Human)

Please avoid freeze-thaw cycles.