KH7,330676-02-3

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

KH7

CAS No. : 330676-02-3

MCE 国际站：KH7

产品活性：KH7 是一种可溶性腺苷酸环化酶 (sAC) 的特异性抑制剂，其在细胞中测得对重组sAC_t 蛋白 (人源和其它) 的 IC₅₀ 值为 3-10 μM。KH7 也是 cAMP 的抑制剂。

研究领域：GPCR/G Protein

作用靶点：Adenylate Cyclase

In Vitro: KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium.
KH7 prevents the generation of CaSF.
In the presence of KH7, the myocytes exerts a negative inotropic effect (NIE) of approximately 20%, suggesting that sAC is involved in the normal generation of basal cardiac contractility.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Membrane Protein-targeted Compound Library  |  Cysteine Targeted Covalent Library  |  Highly Selective Inhibitors Library  |  Forskolin  |  SQ22536  |  Cholera toxin  |  2',5'-Dideoxyadenosine  |  NKH477  |  LRE1  |  TDI-10229  |  Fipexide  |  SKF-83566  |  ST034307  |  NKY80  |  TDI-11861  |  Guanylyl imidodiphosphate lithium  |  Lysipressin acetate  |  TIP 39, Tuberoinfundibular Neuropeptide  |  9-Cyclopentyladenine monomethanesulfonate  |  CB-7921220  |  Adenylyl cyclase type 2 agonist-1  |  NB001  |  Small Cardioactive Peptide B (SCPB)  |  AC1-IN-1  |  Albanin A  |  Angiopeptin TFA  |  Mant-GTPγS triammonium  |  MDL12330A  |  Adenylyl cyclase-IN-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds