- ￥960 - 1600
- Solarbio
- 北京
- K006819P
- 2025年07月13日
- Rabbit
- Human Mouse Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human PIWIL4
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human Mouse Rat
- 目录编号：
K006819P
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 靶点：
PIWIL4
- 抗体英文名：
Anti-PIWIL4 Polyclonal Antibody
- 抗体名：
HIWI2;MIWI2
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 英文名称 | Anti-PIWIL4 Polyclonal Antibody |
| 中文名称 | piwi样蛋白 4抗体 |
| 靶标 | PIWIL4 |
| 别名 | HILI 2, HILI2, HIWI 2, HIWI2, Miwi 2 protein, Miwi2, PIWI, Piwi like 2, Piwi like 4 (Drosophila), Piwi like 4, Piwi like protein 4, PIWI like protein, Piwi-like protein 4, PIWIL 4, Piwil4, PIWL4_HUMAN |
| 背景资料 | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus. May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci. In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors. |
| Swiss Prot | Q7Z3Z4 |
| Gene ID | 143689 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 蛋白分子量 | 52/56/96kDa |
| 稀释比例 | IHC 1:50-200. |
| 免疫原 | Recombinant protein of human PIWIL4 |
| Public Immunogen Range | 503-853aa |
| 纯化方法 | Affinity purification |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 交叉反应 | Human Rat Mouse |
| 应用 | IHC |
| 规格 | 50ul 100ul |
| 单位 | 支 |
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Immunohistochemistry of paraffin-embedded Human thyroid cancer using PIWIL4 antibody diluted at 1:100
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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