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- 2026年08月13日
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- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Cardamonin
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
19309-14-9
- 规格：
10mg/5mg/25mg/50mg/100mg
| 规格： | 10mg | 产品价格： | ¥390.00 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ¥236.00 |
| 规格： | 25mg | 产品价格： | ¥690.00 |
| 规格： | 50mg | 产品价格： | ¥1040.00 |
| 规格： | 100mg | 产品价格： | ¥1565.00 |
| CAS | 19309-14-9 |
| 中文名称 | 小豆蔻明 |
| 英文名称 | Cardamonin |
| 别名 | 小豆蔻明;alpinetinchalcone; |
| 分子式 | C16H14O4 |
| 分子量 | 270.28 |
| 规格 | 10mg ; 5mg ; 25mg ; 50mg ; 100mg |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 级别 | Cell Culture |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| EC | 663-565-8 |
| MDL | MFCD00238554 |
| SMILES | O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2.[E] |
| InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| PubChem CID | 641785 |
| 靶点 | TRP Channel;NF-κB |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling;NF-κB |
| 背景说明 | Cardamonin是hTRPA1阳离子通道拮抗剂，也是NF-kB抑制剂。 |
| 生物活性 | (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.[1-2] |
| IC50 | 454nM(hTRPA1 cation channel)[1] |
| In Vitro | Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway，which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase(MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1]. |
| In Vivo | Cardamonin inhibits tumor growth in vivo without serious side effects[2]. |
| 细胞实验 | Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO，absorbance is measured after 24，48 and 72 h of treatment.[2] |
| 动物实验 | Animal Models: Xenograft model(BALB/c nude mice); Dosages: 5 mg/kg; Administration: i.p.[2] |
| 数据来源文献 | [1] Wang S， et al. Molecules. 2016 Aug 29;21(9):pii: E1145. [2] Yuting Li， et al. Cell Death Dis. 2017， 8(8): e3024. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|3.6999mL|18.4993mL|36.9987mL|$$|5mM|0.74mL|3.6999mL|7.3997mL|$$|10mM|0.37mL|1.8499mL|3.6999mL| |
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis
Author：
Chenglong Xie, Haiwei Ma, Yifeng Shi, Junli Li, Hongqiang Wu, Ben Wang, Zhenxuan Shao, Chongan Huang, Jiaoxiang Chen, Liaojun Sun, Yifei Zhou, Naifeng Tian, Yaosen Wu, Weiyang Gao, Aimin Wu, Xiangyang Wang, Xiaolei Zhang
IF：
5.3960
Publish_to：
Food & Function
PMID：
33666626
Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway
Author：
Wu Yuehan, Wang Yapei, Liu Han, Hu Qiannan, Xie Yuqi, Nan Xiaoxu, He Huan, Liu Ying
IF：
3.8000
Publish_to：
Scientific Reports
PMID：
39242879
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小豆蔻明
¥236 - 1565
