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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Cardamonin
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
19309-14-9
- 规格：
100mg/50mg/25mg/5mg/10mg
| 规格： | 100mg | 产品价格： | ￥1565.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥1040.0 |
| 规格： | 25mg | 产品价格： | ￥690.0 |
| 规格： | 5mg | 产品价格： | ￥236.0 |
| 规格： | 10mg | 产品价格： | ￥390.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway
成员:Wu Yuehan, Wang Yapei, Liu Han, Hu Qiannan, Xie Yuqi, Nan Xiaoxu, He Huan, Liu Ying
论文因子:3.8 发表期刊:Scientific Reports pmid:39242879
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis
成员:Chenglong Xie, Haiwei Ma, Yifeng Shi, Junli Li, Hongqiang Wu, Ben Wang, Zhenxuan Shao, Chongan Huang, Jiaoxiang Chen, Liaojun Sun, Yifei Zhou, Naifeng Tian, Yaosen Wu, Weiyang Gao, Aimin Wu, Xiangyang Wang, Xiaolei Zhang
论文因子:5.396 发表期刊:Food & Function pmid:33666626
| 基本信息 | |
| CAS | No.19309-14-9 |
| 中文名称 | 小豆蔻明 |
| 英文名称 | Cardamonin |
| 别名 | 小豆蔻明;alpinetinchalcone; |
| 分子式 | C16H14O4 |
| 分子量 | 270.28 |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00238554 |
| SMILES | O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2.[E] |
| InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| PubChem CID | 641785 |
| 靶点 | TRP Channel;NF-κB |
| 通路 | Membrane Transporter&Ion Channel;Neuronal Signaling;NF-κB |
| 背景说明 | Cardamonin是hTRPA1阳离子通道拮抗剂，也是NF-kB抑制剂。 |
| 生物活性 | (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.[1-2] |
| IC50 | 454nM(hTRPA1 cation channel)[1] |
| In Vitro | Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway，which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase(MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1]. |
| 细胞实验 | Cardamonin inhibits tumor growth in vivo without serious side effects[2]. |
| 细胞实验 | Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO，absorbance is measured after 24，48 and 72 h of treatment.[2] |
| 动物实验 | Animal Models: Xenograft model(BALB/c nude mice); Dosages: 5 mg/kg; Administration: i.p.[2] |
| 数据来源文献 | [1] Wang S， et al. Molecules. 2016 Aug 29;21(9):pii: E1145. [2] Yuting Li， et al. Cell Death Dis. 2017， 8(8): e3024. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway
成员:Wu Yuehan, Wang Yapei, Liu Han, Hu Qiannan, Xie Yuqi, Nan Xiaoxu, He Huan, Liu Ying
论文因子:3.8 发表期刊:Scientific Reports pmid:39242879
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis
成员:Chenglong Xie, Haiwei Ma, Yifeng Shi, Junli Li, Hongqiang Wu, Ben Wang, Zhenxuan Shao, Chongan Huang, Jiaoxiang Chen, Liaojun Sun, Yifei Zhou, Naifeng Tian, Yaosen Wu, Weiyang Gao, Aimin Wu, Xiangyang Wang, Xiaolei Zhang
论文因子:5.396 发表期刊:Food & Function pmid:33666626
CDllb 常用单克隆抗体或代号：Mol，OKM1；(Macl，CR3，整合素αM) 主要表达细胞：G，M，T， B， DC， NK，Mac[AS] 分子质量(kDa)和结构：gp170(整合素α) 功 能：iC3b和Fs受体，与ICAM-l和X因子结合，黏附，调理吞噬；结合JAM-3 CDllc 常用单克隆抗体或代号：LeuM乳(CR4．整合素αX) 主要表达细胞：M，G，B
(glutathione s-conjugate export carrier, GS-X pump)的泵活性将这些药物泵出细胞外，从而产生耐药性。已有研究表明GST与头颈部肿瘤MDR有关，尤其是鳞癌。有报道GST-π已成为头颈部鳞癌原发及继发病灶早期诊断的血清学诊断依据［2］。 多药耐药相关蛋白(multidrug resistance-associated protein，MRP) 是一种膜糖蛋白。MRP与P-gp同属于三磷酸腺苷依赖性跨膜转运蛋白类，它们在分子
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