AZD1080(≥98%)北京厂家

• DMSO 52mg/mL
• Water<1 mg/mL
• Ethanol<1 mg/mL

Description:
IC50 Value:31 nM[1]
AZD1080 is a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies.
in vitro:AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain.Interestingly,subchronic but not acute administration with AZD1080 reverses MK-801-induced deficits,measured by long-term potentiation in hippocampal slices and in a cognitive test in mice,suggesting that reversal of synaptic plasticity deficits in dysfunctional systems requires longer term modifications of proteins downstream of GSK3βsignaling[1].
in vivo:AZD1080 reverses MK-801-induced impairments in mouse model of cognition.AZD1080 treatment significantly prevents MK-801-induced deficits at both time-points(*p<0.05;**p<0.01).Data are presented as mean _ SEM(n = 9-12 subjects/group).[1]
Clinical trial:Phase 1