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Recombinant Human Fc-Epsilon R

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  • ¥1080 - 45885
  • Prospecbio
  • 以色列
  • pro-1741
  • 2026年01月15日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      FCER1A

    • 库存

      常规产品有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      5ug/20ug/1mg

    规格:5ug产品价格:¥1080.0
    规格:20ug产品价格:¥2415.0
    规格:1mg产品价格:¥45885.0

    产品细节图片1

    CATALOGUE NUMBER

    PRO-1741

    SYNONYMS

    Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide, FCE1A, IgE Fc Receptor Subunit Alpha, FcERI, Fc-Epsilon RI-Alpha, Fc Epsilon RI Alpha-Chain, Fc IgE Receptor, Alpha Polypeptide, High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit, High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha, Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide.

    INTRODUCTION

    Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (FCER1A) binds to the Fc region of immunoglobulins epsilon. FCER1A is a high affinity receptor. In addition FCER1A is responsible for starting the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamine which is responsible for the manifestations of allergy. This receptor is contains of an alpha subunit, a beta subunit, and two gamma subunits. FCER1A stands for the alpha subunit. Among the diseases associated with FCER1A are mast-cell leukemia, and allergic asthma.

    DESCRIPTION

    FCER1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (26-205aa) and having a molecular mass of 23.4kDa.
    FCER1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    SOURCE

    Escherichia Coli.

    PHYSICAL APPEARANCE

    Sterile Filtered clear solution.

    FORMULATION

    FCER1A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Please avoid freeze thaw cycles.

    PURITY

    Greater than 85% as determined by SDS-PAGE.

    AMINO ACID SEQUENCE

    MG/S.SHHHHHH SSGLVPRGSH MGSVPQKPKV SLN.P.PWNRIF KGENVTLTCN GNNFFEVSST KWFHNGSLSE ETNSSLNIVN AKFEDSGEYK CQHQQVNESE PVYLEVFSDW LLLQASAEVV MEGQPLFLRC HGWRNWDVYK VIYYKDGEAL KYWYENHNIS ITNATVEDSG TYYCTGKVWQ LDYESEPLNI TVIKAPREKY WLQ

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献
    FCER1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (26-205aa) and having a molecular mass of 23.4kDa.
    FCER1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
    相关实验
    • 免疫球蛋白Fc段受体FcεRI/ FcεRⅡ

      免疫球蛋白 Fc 段受体 Fc ε RI/ Fc ε R Ⅱ FcεRI 由一条。链、一条p链和YY二聚体所组成(op丁2)。FctRI。链属IgSF成员,胞膜外区有2个C2样结构域,跨膜区与CDl6跨膜区同源性很高。p链是CD20/FctRIp家族成员。丁链则与FcTRⅢ丁亚单位完全相同,并与CD3(和7)链结构相似。FctRIT链胞质区含有ITAM。FctRI是IgE高亲和力受体,相互结合的部位是FctRa第1个IgSF结构域与IgE重链第3个恒定区Ce3。FceRI丁链

    • Quantification of Human IgG and Related Fc Fusion Proteins by a Human IgG/Fc Capture ELISA

      of recombinant human IgGs after production and purification for further assays. Here, we describe a human IgG/Fc capture enzyme linked immunosorbent assay (ELISA) which is simple, robust, inexpensive and specific for all types of human IgGs and related Fc fusion

    • 肥大细胞产生的介质--FcγRI的作用

      肥大细胞产生的介质--Fc γRI 的作用       一般情况下,只有当其表面的FcεRI发生抗原依赖的聚集后,肥大细胞才释放促炎症介质。但有些时候,其他受体包括IgG高亲和力受体(FcγRl)、c-Kit、补体C3a受体及腺苷受体,也同样可以诱发或增强肥大细胞的活化。IgG受体(FcγR)的作用具有双重性,可以促进也可以抑制肥大细胞的活化。有关应答具有物种专一性,并依赖于肥大细胞的表型特征。       人类CD34阳性肥大细胞在IFN-γ作用下Fc

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    文献支持
    Recombinant Human Fc-Epsilon RI-Alpha
    ¥1080 - 45885