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Recombinant Human Tumor Necros

is Factor-alpha, sf9
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  • ￥1080 - 87906
  • Prospecbio
  • 以色列
  • cyt-903
  • 2025年12月28日
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    上海经科化学科技有限公司
    16 年钻石会员

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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件：

      for future use below -18°C

    • 保质期：

      See instructions

    • 英文名：

      TNFA, Sf9

    • 库存：

      部分小规格有备货

    • 供应商：

      上海经科化学科技有限公司

    • CAS号：

      无

    • 规格：

      2ug/10ug/1mg

    规格：2ug产品价格：￥1080.0
    规格：10ug产品价格：￥2415.0
    规格：1mg产品价格：￥87906.0

    产品细节图片1

    CATALOGUE NUMBER

    CYT-903

    SYNONYMS

    Tumor Necrosis Factor, TNFA, Tumor Necrosis Factor Ligand Superfamily Member 2, Cachectin, TNF-Alpha, TNFSF2, TNF-A, Tumor Necrosis Factor (TNF Superfamily, Member 2), Tumor Necrosis Factor-Alpha, TNF, Macrophage-Derived, TNF, Monocyte-Derived, TNF Superfamily, APC1 Protein, Member 2, DIF, Tumor necrosis factor.

    INTRODUCTION

    Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages.
    TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells.
    Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.

    DESCRIPTION

    TNF a produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 163 amino acids (77-233a.a.) and having a molecular mass of 18.1kDa. 
    (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).
    TNF a is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

    SOURCE

    Sf9, Baculovirus cells.

    PHYSICAL APPEARANCE

    Sterile Filtered clear solution.

    FORMULATION

    TNF a protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks.
    Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Please avoid freeze thaw cycles.

    PURITY

    Greater than 90.0% as determined bySDS-PAGE.

    BIOLOGICAL ACTIVITY

    Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. 
    The ED50 for this effect is ≤ 0.2 ng/ml.

    AMINO ACID SEQUENCE

    VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIALHHH HHH.

    SAFETY DATA SHEET

    SDS

    USAGE

    Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    TNF a produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 163 amino acids (77-233a.a.) and having a molecular mass of 18.1kDa. 

    (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).
    TNF a is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
    相关实验

    • Typing of Tumor Necrosis Factor Alleles

      The tumor necrosis factor (TNF) locus contains the three closely related cytokine genes: TNF , and lymphotoxin α and �. The gene cluster lies at the telomeric end of the class III region of the major histocompatibility complex (MHC

    • Tumor Necrosis Factor as a Pharmacological Target

      Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it was found to be identical to cachectin

    • Assay of Soluble Tumor Necrosis Factor Receptors

      Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1 –

    查看更多相关实验 >

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    文献支持
    Recombinant Human Tumor Necrosis Factor-alpha, sf9
    ￥1080 - 87906