- ￥5300
- GeneTex
- 美国
- GTX78935
- 2025年07月14日
- WB, IHC-P
- Rabbit
- Human
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- 文献和实验
- 技术资料
- 免疫原：
The antiserum was produced against synthesized phosphopeptide derived from human STAT6 around the phosphorylation site of Tyrosine 641 (R-G-Yp-V-P).
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12 months from the shipping date of the product.
- 抗原来源：
Human
- 目录编号：
GTX78935
- 级别：
Primary Antibodies
- 库存：
Available
- 供应商：
GeneTex
- 宿主：
Rabbit
- 应用范围：
WB, IHC-P
- 浓度：
Batch dependent (Please refer to the vial label for the specific concentration.)
- 靶点：
STAT6 (phospho Tyr641)
- 抗体英文名：
STAT6 (phospho Tyr641) antibody
- 抗体名：
STAT6 (phospho Tyr641) 抗体
- 规格：
100 μg
IHC-P analysis of human breast carcinoma tissue using GTX78935 STAT6 (phospho Tyr641) antibody.
WB analysis of extract from HeLa cells treated with IL-4 using GTX78935 STAT6 (phospho Tyr641) antibody.
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文献和实验【热门靶点解析】STAT6 生物学功能、信号通路及相关疾病中的核心作用
因子，在2型免疫应答中发挥核心调控作用。 它主要在CD4⁺ T细胞（尤其是Th2亚群）、B淋巴细胞、巨噬细胞和树突状细胞中高表达。当IL-4或IL-13与其受体结合后，激活JAK激酶，使STAT6在Y641位点发生磷酸化，形成同源二聚体并转位至细胞核，结合靶基因启动子区的特异性应答元件，启动转录。 STAT6可驱动Th2细胞分化（如上调GATA3及IL-4、IL-5、IL-13表达），介导B细胞IgE类别转换，并促进巨噬细胞向M2型极化。其活性受到多重负反馈机制的精细调控，包括磷酸酶去磷酸化、SOCS蛋白
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
Optimized Protocol to Make Phospho-Specific Antibodies that Work
, not simply its level of expression. In this review, we will discuss both the design of the phosphopeptide immunogen and immunization. The affinity purification of the phospho-specific antibody as well as the methods most suitable for characterizing
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