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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Purified rat Cdk5
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human, Mouse, Rat
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Rat
- 目录编号:
GTX82727
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
WB, IHC
- 浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
- 靶点:
CDK5
- 抗体英文名:
CDK5 antibody [1H3]
- 抗体名:
CDK5 抗体 [1H3]
- 规格:
100 μl
Western blot of rat caudate lysate showing specific immunolabeling of the ~28k Cdk5 protein using CDK5 antibody [1H3] (GTX82727).
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文献和实验如何“偷走”记忆? 记忆并不是突然消失的,它是在突触一场场功能失衡中,被一点点“偷走”的。 Aβ 通过以下方式破坏突触: • Aβ 干扰谷氨酸循环:增加释放、抑制 EAAT1/EAAT2 转运体对谷氨酸的回收,导致突触外 NMDAR 过度激活。 • 引发钙超载:过度激活的 NMDAR 引发 Ca2+ 内流,造成钙超载,一旦 Ca2+ 失控,后续反应就像被推倒的多米诺骨牌:LTP 被抑制,LTD 被放大,CDK5 和 GSK-3β 被持续激活,tau 蛋白逐步偏离正常轨道。 此外,AβO
kinase assays toward cdk2, cdk5, and25 other kinases (23) . Currently thiadiazolidinone (TDZD) isthe only ATP-noncompetitive inhibitor of GSK-3 (24) . While theexact mechanism by which TDZD inhibits GSK-3 kinase activityis unclear, it has been suggested
., et al. 「Epigenetic and genetic features of 24 colon cancer cell lines.」 Oncogenesis 2.9 (2013): e71.【2】Messner, Isabelle, et al. 「KRAS p. G13D mutations are associated with sensitivity to anti-EGFR antibody treatment in colorectal cancer cell lines
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