- ￥4700
- GeneTex
- 美国
- GTX75843
- 2025年07月10日
- ICC/IF, IHC-Fr, FACS, IP, ELISA
- Mouse
- Human, Monkey, Chimpanzee
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified human Granzyme B.
- 亚型：
IgG1
- 形态：
Liquid
- 保存条件：
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human, Monkey, Chimpanzee
- 保质期：
12 months from the shipping date of the product.
- 抗原来源：
Human
- 目录编号：
GTX75843
- 级别：
Primary Antibodies
- 库存：
Available
- 供应商：
GeneTex
- 宿主：
Mouse
- 应用范围：
ICC/IF, IHC-Fr, FACS, IP, ELISA
- 浓度：
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点：
This antibody has been reported to function as a capture reagent in sandwich ELISA assays for soluble Granzyme B in conjunction with biotin conjugated GB10 (GTX75842) as detection reagent.
- 抗体英文名：
Granzyme B antibody [GB11]
- 抗体名：
Granzyme B 抗体 [GB11]
- 规格：
50 μg
Sandwich ELISA analysis of human granzyme B using Mouse anti Human granzyme B (GTX75843) as a capture reagent and biotinylated Mouse anti Human granzyme B (GTX75842) as a detection reagent. Human plasma samples are diluted i:2 (green) and 1:4 (blue).
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文献和实验Clayberger C et al., J Immunol 2012 (PMID:22586033)
Nishie M et al., Cancer Immunol Immunother 2020 (PMID:33000417)
McNeel DG et al., Clin Cancer Res 2014 (PMID:24850844)
and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors
Immunodetection of Granzyme B Tissue Distribution and Cellular Localisation
Investigation of Granzyme B (GrB) function and pathophysiology in both human settings and rodent models increasingly involve the use of indirect immunofluorescence imaging and fluorescence-activated cell sorting, which requires reliable GrB
Detection of Human and Mouse Granzyme B Activity in Cell Extracts
The serine protease granzyme B (GrB) is a key effector molecule in cell-mediated immunity, released by cytotoxic lymphocytes (CLs) to induce cell death in neoplastic or virus-infected cells. The ability to detect and measure GrB activity
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