Anti-NLRP3 Rabbit Polyclonal A

gene_symbol：NLRP3
predicted_size：null
Uniprot ID：Q96P2
description：Anti-NLRP3 Rabbit Polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.?
immunogen：Fusion protein corresponding to a region derived from 1-301 amino acids of human NLR family, pyrin domain containing 3
recommended_dilution：IHC: 15-50 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
predicted_size：null
buffer：PBS pH7.3, 0.05% NaN3, 50% glycerol
host_species：Rabbit
applications：IHC
reactivities：Human