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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
GST fusion protein corresponding to full-length human 14-3-3 sigma
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human, Mouse, Rat
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Human
- 目录编号:
GTX14122
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
WB, IP
- 浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
- 靶点:
Recognizes human 14-3-3 sigma, Mr 30kD. Does not crossreact with other 14-3-3 isoforms.
- 抗体英文名:
14-3-3 sigma antibody [1.T.28]
- 抗体名:
14-3-3 sigma 抗体 [1.T.28]
- 规格:
50 μg
WB analysis of A431 cell lysate using GTX14122 14-3-3 sigma antibody [1.T.28].
Dilution : 0.5μg/ml
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文献和实验机体免疫应答过程的复杂性和严格的调控性,是由多种免疫细胞和免疫分子共同参与完成的。而T淋巴细胞的活化,在免疫应答中扮演着相当重要的角色。研究表明,诱导T细胞的活化与增殖需要两种信号:一种是 TCR/CD3 与抗原提呈细胞(APCs)表面特异的 MHCⅡ 抗原肽复合物结合产生的特异性抗原刺激信号;另一种是非特异性协同刺激信号,由 APCs 表面的协同刺激分子和 T 细胞的相应受体相互作用后产生,其中 CD28/B7 是最为重要的协同刺激分子,能增加 IL-2 的产生,加速T细胞增殖,阻止细胞进入
, which have been associated with many diverse functions including critical roles in signal transduction pathways, exocytosis and cell cycle regulation. We report here the crystal structure of the human T-cell 14-3-3 isoform (tau) dimer at 2.6 A resolution. Each monomer (Mr 28
Simultaneous Quantification of t(14;18) and HPRT Exon 2/3 Deletions in Human Lymphocytes
is required for the formation of functional T-cell receptor genes in T cells and antibody genes in B cells. This is an inherently dangerous process, however, because double-strand breaks are introduced into the chromosomes. Molecular evidence indicates
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