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- 文献和实验
- 技术资料
- 英文名：
Dofetilide
- 供应商：
上海恪敏生物科技有限公司
- CAS号：
115256-11-6
- 规格：
5mg
Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
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文献和实验相关实验
A High-Throughput Binding Assay for HERG
. However, these are time-consuming and expensive, and so a simple assay, suitable for general laboratory use, would be beneficial. The authors have established a radioligand binding assay that utilizes [3 H]dofetilide and membranes prepared from HEK293 cells stably
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￥100 - 9999
