Rabbit Polyclonal Anti-TPSB2 A

gene_symbol：TPSB2
predicted_size：null
Uniprot ID：P2231
description：Rabbit Polyclonal Anti-TPSB2 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
immunogen：Full length fusion protein
recommended_dilution：WB: 200-1000 WB positive control: Human fetal muscle tissue lysate IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Secreted
predicted_size：null
buffer：pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
host_species：Rabbit
applications：IHC, WB
reactivities：Human