MHC Class I Heavy Chain (Restr

gene_symbol：null
predicted_size：null
Uniprot ID
description：MHC Class I Heavy Chain (Restricted expression) mouse monoclonal antibody, clone HC10, Purified
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The HLA class I gene family is composed of a group of genes whose products encode cell surface glycoproteins of MW 40–45 kDa, associated non-covalently with the beta-2-microglobulin light chain. They include the three polymorphic molecules HLA-A, -B, and -C, which are ubiquitously expressed and which are able to present intracellular peptides to cytotoxic T cells. Three additional class I genes are known, commonly referred to as non-classical or class Ib genes, all highly homologous to the other class I genes and all of which associate with beta-2-microglobulin light chain. In humans, each of the class Ib genes appears to exhibit a distinct pattern of expression in developing and adult tissues. HLA-E transcripts are distributed widely in adult tissues and have also been found in the placenta and fetal liver. In the adult, the presence of HLA-F has been shown in skin, resting T cells, and B cells, whereas its expression during development has been reported in fetal liver and at low levels in placenta and extra-placental tissues. HLA-G was originally thought to be expressed only in certain populations of placental trophoblasts, but low levels have also been found in a variety of human tissues. Recently it was shown that HLA class I expression in breast cancer cells can have a predictive value for chemotherapy response.
immunogen：Derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from BALB/c mice immunized with HLA-B7 and -B40 heavy chains
recommended_dilution：Electron microscopy. ELISA.  Western Blot. Immunoprecipitation. Flow Cytometry.  Immunocytochemistry. Immunohistochemistry on Frozen Sections.  Immunohistochemistry on Paraffin Sections. Recommended Dilutions : 1/100-1/200 for Flow Cytometry and for Immunohistochemistry with avidin-biotinylated Horseradish Peroxidase complex (ABC) as detection reagent, and 1/100-1/1000 for Immunoblotting applications.
predicted_size：null
buffer：PBS; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
host_species：Mouse
applications：ELISA, EM, FC, IF, IHC, IP, WB
reactivities：Human