人尿胰蛋白酶抑制剂（UTI）

产品英文名称：
Recombinant Human Urinary Trypsin Inhibitor （UTI）

英文简称:
Ulinastatin

中文名称:
重组人尿胰蛋白酶抑制剂（UTI）

背景资料:
Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor with a molecular weight of about 67，000 derived from human urine which inhibits the activity of trypsin， chymotrypsin， lactate， lipase， hyaluronidase and various pancreatic enzymes. Ulinastatin is e毕赤酵母中重组表达ective for acute pancreatitis， chronic recurrent pancreatitis and hemorrhagic， traumatic and endotoxic shocks. Ulinastatin is has strong inhibition e毕赤酵母中重组表达ect to various protease， sugar and fat hydrolase. Ulinastatin precursor is proteolytically processed into distinct functioning proteins. urinary trypsin inhibitor belongs to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. Uristatin gene is located on chromosome 9 in a cluster of lipocalin genes. High levels of Ulinastatin secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane. FrRecombinant Ulinastatin produced in Yeast is a single， glycosylated， polypeptide having 143 amino acids， molecular mass of 20 kDa and predicted pI of 4.5. uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. Ulinastatin particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte.

产品描述:
Recombinant Ulinastatin produced in Yeast is a single， glycosylated， polypeptide having 143 amino acids， molecular mass of 20 kDa and predicted pI of 4.5.
来源宿主:
毕赤酵母中重组表达

序列:
AVLPQEEEGS GGGQLVTEVT KKEDSCQLGY SAGPCMGMTS RYFYNGTSMACETFQYGGCM GNGNNFVTEK ECLQTCRTVA ACNLPIVRGP CRAFIQLWAFDAVKGKCVLF PYGGCQGNGN KFYSEKECRE YCGVPGDGDE ELL.

溶解建议:
Sterile Filtered solution. Formulated in 1X PBS.

保存建议：
Ulinastatin although stable at 15℃ for 2 weeks， should be stored desiccated below -18℃. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。