产品英文名称: Recombinant Human Nei Endonuclease VIII-Like 2
英文简称: NEIL2
中文名称: 重组人内切核酸酶8样蛋白2
背景资料: Endonuclease 8-like 2(NEIL2) is a member of a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases set o大肠杆菌中重组表达 the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break through the associated lyase reaction. NEIL2 is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL2 has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA(DNA bubbles). NEIL2 has insignificant or undetectable activity with 8-oxoguanine, thymine glycol, 2-hydroxyadenine, hypoxanthine, and xanthine. NEIL2 also has AP(apurinic/apyrimidinic) lyase activity and creates incisions in the DNA strand. NEIL2 cleaves the DNA backbone by beta-delta exclusion to produce a single-strand break at the site of the removed base with both 3’- and 5’-phosphates. NEIL2 is found in the testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
产品描述: NEIL2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 356 amino acids(1-332) and having a molecular mass of 39.4kDa.NEIL2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达