背景资料: Sialidase 1(NEU1) is a lysosomal enzyme which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, the NEU1 enzyme is part of a heterotrimeric complex in cooperation with beta-galactosidase and cathepsin A. NEU1 gene mutations may lead to sialidosis, a lysosomal storage disease that can be the type 1(cherry red -myoclonus syndrome or normosomatic type), which is late-onset, or the type 2(the dysmorphic type), which takes place at an earlier age with increased acuteness.
产品描述: NEU1 Human Recombinant produced in E. coli is a single polypeptide chain containing 393 amino acids(48-415) and having a molecular mass of 42.9 kDa.NEU1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达