H3N2 Neuraminidase/NA蛋白|Neuraminidase/NA protein|Neuraminidase/NA(H3N2, Native)(产品说明)
蛋白名称:Neuraminidase/NA蛋白, Neuraminidase/NA protein
蛋白构建:A DNA sequence encoding the Influenza A virus (A/Babol/36/2005 (H3N2)) neuraminidase (ACN50232.1) (His 36-Pro 459) was expressed, the cell lysates are collected, and bio-activity was tested. There is an amino acid change from Histidine to Tyrosine (H274Y mutation) in NA / Neuraminidase.
表达宿主:HEK293 Cells
蛋白纯度:0
蛋白活性:Measured by its ability to cleave a fluorogenic substrate, 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid.The specific activity is > 1,000 U.One unit is defined as the amount of enzyme required to cleave 1 nmole of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid per minute at pH 7.5 at 37℃.
蛋白内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
预测N端:0
蛋白分子量:The influenza H3N2 virus Neuraminidase comprises 424 amino acids.
蛋白NP号:ACN50232.1
蛋白氨基酸序列:His36-Pro459
蛋白标签:Native
蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
1, Lao, Z; et al. Synthetic pentatrideca-valent triazolylsialoside inhibits influenza virus hemagglutinin/neuraminidase and aggregates virion particles. European Journal of Medicinal Chemistry
2, Ju, H; et al. Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity. European Journal of Medicinal Chemistry