- ￥99 - 999
- Sigma
- 进口
- SML0897-5MG
- 2025年12月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 库存：
现货
- 供应商：
联硕生物
- CAS号：
200006-08-2
- 规格：
1瓶
应用
ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs).[1] It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.[2]
生化/生理作用
ALX 5407 is a selective, irreversible GlyT-1 glycine transporter inhibitor.
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
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文献和实验Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.
Valérie de Crécy-Lagard et al.
Molecular biology and evolution, 27(9), 2062-2077 (2010-04-13)
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