Anti-TRPC4AP antibody

Anti-TRPC4AP antibody

Cat. No.     JC223428
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TRPC4AP rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human TRPC4AP
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 TRPC4AP
Full name                 transient receptor potential cation channel, subfamily C, member 4 associated protein
Synonyms    TRUSS; TRRP4AP; PPP1R158; C20orf188
Swissprot    Q8TEL6

Target Background
TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein), also known as TRUSS or TRRP4AP, is a 797 amino acid protein that is expressed in a variety of tissues, with highest expression in liver, heart, testis and brain. Thought to function as a scaffolding protein, TRPC4AP interacts with TNF-R1 and may both link TNF-R1 to the IKK signalsome complex, and participate in the activation of NFκB p50, an event that occurs in response to TNF-R1 ligation. TRPC4AP exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human thyroid cancer
Recommended dilution: 25-100