Anti-MAFA antibody

Anti-MAFA antibody

Cat. No.    JC162795
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MAFA rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human MAFA
Reactivity                 Human, Mouse
Content                     1.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-MAFA antibody
Target information
Symbol                 MAFA
Full name                 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
Synonyms    hMafA; RIPE3b1
Swissprot    Q8NHW3

Target Background
Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity.

Anti-MAFA antibody
Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human liver cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 25-100