Anti-ASH2L antibody

Anti-ASH2L antibody

Cat. No.     JC221917
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ASH2L rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human ASH2L
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ASH2L
Full name                 ash2 (absent, small, or homeotic)-like (Drosophila)
Synonyms    ASH2; Bre2; ASH2L1; ASH2L2
Swissprot    Q9UBL3

Target Background
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Alternative splicing results in a shorter isoform 2, designated ASH2L2, which is missing the first 94 amino acid residues found in ASH2L1. Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. ASH2L is highly expressed in fetal liver, testis and leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami.

Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human colon cancer
Recommended dilution: 50-200    Predicted cell location: Nucleus
Positive control: Human liver cancer
Recommended dilution: 50-200