Anti-KRT6A/KRT6B/KRT6C antibod

Anti-KRT6A/KRT6B/KRT6C antibody

Cat. No.    JK160177     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-KRT6A/KRT6B/KRT6C rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human KRT6A/KRT6B/KRT6C
Reactivity                 Human, Mouse
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 KRT6A/KRT6B/KRT6C
Full name                 keratin 6A/keratin 6B/keratin 6C
Synonyms    K6A; K6C; K6D; CK6A; CK6C; CK6D; KRT6C; KRT6D; K6B; PC2; CK6B; CK-6B; KRTL1; K6E; KRT6E
Swissprot    P02538/P04259/P48668

Target Background
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.