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- Signalway Antibody
- USA
- AP79085
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Segment polarity protein dishevelled homolog DVL-1
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:DSH homolog 1
accession_no:O14640
Gene name:DVL1
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
产品详细信息请点击：Segment polarity protein dishevelled homolog DVL-1
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文献和实验Role of Prickle1 and Prickle2 in Neurite Outgrowth in Murine Neuroblastoma Cells
striking neurite-like process formation without RA. Prickle1 and Prickle2 associate with Dishevelled1 (Dvl1) and overexpression of Prickle1 or Prickle2 resulted in the reduction of Dvl1 protein in C1300 cells. Overexpression of Dvl1 in C1300 cells prevented
v468.chapter 1 经典 Wnt/b-Catenin 信号通路 （英文完整版）
., Wagenaar, E.,Parren, P., Weigel, D., and Nusse R. (1987) The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50 , 649–657. 3. McMahon, A. P. and Moon, R. T. (1989) Ectopic expression
v468.Chapter 3 分泌型跨膜相关蛋白提纯及Wnt抑制活性
). 2. Dishevelled (Dvl)-2 primary antibody: clone 10B5 (sc-8026;Santa Cruz Biotechnology). 3. Dvl-3 primary antibody: clone 4D3 (sc-8027; Santa CruzBiotechnology). 4. Secondary antibody to use with mouse monoclonal primaryantibodies: sheep anti-mouse IgG-HRP
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