- 询价
- Signalway Antibody
- USA
- AP77543
- 2025年07月04日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Human papillomavirus type 16 Protein E7(E7)
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 90% as determined by SDS-PAGE.
other_names:
accession_no:P03129
calculated_mw:38 kDa
tag info:N-terminal GST-tagged
Immunogen Description:Expression Region:1-98aa
Sequence Info:Full Length
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1,pRb, which is a key regulator of the cell cycle. Induces the disassbly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription .
产品详细信息请点击：Recombinant Human papillomavirus type 16 Protein E7(E7)
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文献和实验Analysis of E7/Rb Associations
of fundamental events, such as cell proliferation and apoptosis. The best-characterized activity of E7 from HPV type 16, the most frequently detected type in cervical cancer, is its ability to bind and induce degradation of the tumor-suppressor retinoblastoma
Immortalization of Human Prostate Cells With the Human Papillomavirus Type 16 E6 Gene
. With the addition of DU145 the list of human experimental prostate cell systems is almost exhausted, although recently new sets of cell lines, immortalized by viral and nonviral genes, have begun to appear to augment the list (1 –5 ).
cancer cells as a model, we demonstrate RNAi for viral oncogenes Cervical cancer is the second most common cancer in women worldwide and is caused by human papillomavirus (HPV). Silencing of HPV E6 and E7 gene expression was achieved using siRNAs
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