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- 详细信息
- 文献和实验
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- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Mouse Toll-like receptor 4(Tlr4),partial
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:Yeast
purification:Greater than 90% as determined by SDS-PAGE.
other_names:CD_antigen: CD284
accession_no:Q9QUK6
calculated_mw:71.5 kDa
tag info:N-terminal 6xHis-tagged
Immunogen Description:Expression Region:26-638aa
Sequence Info:Partial
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes,macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL
产品详细信息请点击：Recombinant Mouse Toll-like receptor 4(Tlr4),partial
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文献和实验Innate Immunity, Toll-Like Receptors, and Atherosclerosis: Mouse Models and Methods
Chronic inflammation and aberrant lipid metabolism represent hallmarks of atherosclerosis. Innate immunity critically depends upon Toll-like receptor (TLR) signalling. Recent data directly implicate signalling by TLR4 and TLR
Mouse Strains and Genetic Nomenclature
. We also provide some guidance to make the best possible choice when establishing an experimental protocol. Curr. Protoc. Mouse Biol. 1:213?238. © 2011 by John Wiley & Sons, Inc. Keywords: inbred strains; congenic strains; recombinant inbred
pathogen recognition receptor proteins known as Toll-like receptors (TLRs), or by treatment with certain cytokines. Recent microarray studies have shown that one consequence of activation of mouse macrophages is an increased accumulation
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