- 询价
- Signalway Antibody
- USA
- AP77852
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Human Fibroblast growth factor receptor 1(FGFR1),partial
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:Yeast
purification:Greater than 85% as determined by SDS-PAGE.
other_names:Basic fibroblast growth factor receptor 1 Short name: BFGFR Short name: bFGF-R-1 Fms-like tyrosine kinase 2 Short name: FLT-2 N-sam Proto-oncogene c-Fgr CD_antigen: CD331 BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
accession_no:P11362
calculated_mw:55.4 kDa
tag info:N-terminal 6xHis-sumostar-tagged
Immunogen Description:Expression Region:22-376aa
Sequence Info:Partial
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1,ERK2, MAPK3,ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11,SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD,SEF, and by FGFR1 ubiquitination, internalization and degradation.
产品详细信息请点击：Recombinant Human Fibroblast growth factor receptor 1(FGFR1),partial
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文献和实验their signal by binding to a fibroblast growth factor receptor (FGFR) which has an intracellular protein tyrosine kinase domain. The tyrosine kinase domain is activated upon FGF binding, resulting in the activation of a transcription factor by means of a signal
Regulator of Epidermal Growth Factor Signaling: Sprouty
Sprouty was first discovered through its downregulatory effect on fibroblast growth factor (FGF) receptor pathway during tracheal development. Sprouty expression is also induced by the epidermal growth factor receptor (EGFR) cascade
Culturing BG01V Human Embryonic Stem Cells with Mouse Embryonic Fibroblast (MEF)-Conditioned Media
Supplies Required Reagents MEF-Conditioned Media (R&D Systems, Catalog # AR005 ) or Human Feeder Cell-Conditioned Media (R&D Systems, Catalog # AR007 ) Recombinant human FGF basic (R&D Systems, Catalog # 233-FB ) or tissue culture
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