Product overview
Description Anti-SRGAP3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human SRGAP3
Reactivity Human, Mouse
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-SRGAP3 antibody Target information
Symbol SRGAP3
Full name SLIT-ROBO Rho GTPase activating protein 3
Synonyms WRP; MEGAP; SRGAP2; ARHGAP14
Swissprot O43295
Target Background
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Anti-SRGAP3 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100