Product overview
Description Anti-CASP8AP2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human CASP8AP2
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CASP8AP2
Full name caspase 8 associated protein 2
Synonyms CED-4; FLASH; RIP25
Swissprot Q9UKL3
Target Background
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human brain
Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml261684(CASP8AP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)