Anti-CNOT10 antibody

Anti-CNOT10 antibody

Cat. No.     JK124600  
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CNOT10 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CNOT10
Reactivity                 Human, Mouse, Rat
Content                     0.9 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification


Target information
Symbol                 CNOT10
Full name                 CCR4-NOT transcription complex subunit 10
Synonyms    
Swissprot    Q9H9A5

Target Background
CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.