Product overview
Description Anti-APLF rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human APLF
Reactivity Human
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol APLF
Full name aprataxin and PNKP like factor
Synonyms APFL; PALF; Xip1; C2orf13
Swissprot Q8IW19
Target Background
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks. Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro.