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小鼠颗粒酶B蛋白Recombinant Murine Gra

nzyme B
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  • ¥1800
  • pepro
  • 美国
  • 140-03
  • 2025年07月15日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      Recombinant Murine Granzyme B

    • 供应商

      上海研卉生物科技有限公司

    • 规格

      10ug

    小鼠颗粒酶B蛋白Recombinant Murine Granzyme B
    Catalog Number:
    140-03
    Synonyms:
    Cytotoxic cell protease 1 (CCP1)
    Description:
    Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell-mediated immune responses, and can activate apoptosis in target cells by both caspase-dependent and caspase-independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant Murine Granzyme B is a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B precursor. The apparent molecular weight is 28.9 kDa by mass spectrometry.
    AA Sequence:
    IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR GDSGGPLVCK KVAAGIVSYG YKDGSPPRAF TKVSSFLSWI KKTMKSS
    Source:
    Baculovirus
    Purity:
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Biological Activity:
    Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 25οC, is greater than 750 nM/min per μg of enzyme.
    Cross Reactivity:
    Mouse

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    图标文献和实验
    相关实验
    • Granzyme A、B介导的凋亡信号通路

      and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors

    • Immunodetection of Granzyme B Tissue Distribution and Cellular Localisation

      Investigation of Granzyme B (GrB) function and pathophysiology in both human settings and rodent models increasingly involve the use of indirect immunofluorescence imaging and fluorescence-activated cell sorting, which requires reliable GrB

    • Granzyme A、B介导的凋亡信号通路

      and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors

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