- 询价
- gelatins
- JLC163497
- 上海
- 2025年07月16日
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
多克隆
- 抗体名：
Anti-RCOR1 antibody
- 适应物种：
人/动物/植物
- 浓度：
0.5 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Cat. No. JLC163497
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-RCOR1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human RCOR1
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol RCOR1
Full name REST corepressor 1
Synonyms RCOR; COREST
Swissprot Q9UKL0
Target Background
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
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